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BLD Insights


01 April 2024

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Pyrazole and its derivatives have pharmacological activities such as anti-microbial, anti-tumor, anti-viral, anti-depression, etc. The introduction of other cyclic groups on pyrazole can generate a large number of lead compounds, among which the introduction of cyclopropyl plays a variety of roles in drug molecules:

◆ Plasma clearance reducing

◆ Off-target effects decreasing

◆ Blood-brain barrier permeability increasing

◆ Receptor affinity enhancing

◆ Peptide hydrolysis limiting

◆ Drug dissociation improving

It is currently being widely used in drug research by companies such as Merck & Co., Inc. and Hansoh Pharma.