Ready to get more kinds of Boronates from BLDpharm？
23 September 2022
Organobotonates including Bneops, Bcats, Bpinanes as well as [c][1,2]oxaborol-1(3H)-ols have a small number and a large variety compared to Bpins and boronic acids.
Special [c][1,2]oxaborol-1(3H)-ols such as Tavaborole and Crisaborole are BPC. Tavaborole is an antifungal agent that protects against trichophyton and is effective in treating onychomycosis while Tavaborole is a non-steroidal phosphodiesterase 4 (PDE-4) inhibitor. They can also be building blocks used to induce 2-benzyl alcohol group.
Bneops can be used in heteroaryl−heteroaryl SM cross-coupling reaction and C-H activation reaction. Also, due to the good water and fat solubility, they can be applicated for drug delivery. Bis[(-)-pinanediolato]diboron is a chiral reactant and both catalyst.
They have a wide range of applications in pharmaceutical chemistry and synthesis of natural products as well as methodology research.
Martin D. Smith et al. J. Am. Chem. Soc. 2022, 144, 14790–14797.
Scott E. Denmark et al. J. Am. Chem. Soc. 2021, 143, 13845–13853.
Shinji Murai et al. J. Am. Chem. Soc. 2003, 125, 1698–1699.
Huayue Wu et al. Chinese Chem. Lett. 2018, 29, 1795-1798.